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KMID : 0377220010260010032
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Medical Journal of Chosun Univercity
2001 Volume.26 No. 1 p.32 ~ p.39
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REAL Classification and Expression of Cyclin D1, Bcl-2, p53 and Bcl-6 Protein in Non-Hodgkin’s Lymphoma
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Lee Mi-Ja
Jeon Ho-Jong
Chung Chong-Dal
Park Yu-Hoan
Kim Min
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Abstract
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Background and Objectives : There has been a continuous evolution of the lymphoma classification and recently a Revised European-American Lymphoma (REAL) classification was proposed by the International Lymphoma Study Group. This new classification requires information on immunophenotypic and molecular biologic markers in addition to the usual histologic findings. The distinction between mantle cell lymphoma (MCL) and other low grade B cell lymphomas is important because MCL has a more aggressive clinical course. The aim of this study is to determine the clinical characteristics and the relative frequency of malignant non-Hodgkin’s lymphomas (NHL) and analyze the expression of the cyclin D1, bcl-2, p53 and the bcl-6 protein.
Materials and Methods : One hundred and twelve cases of NHL were recategorized by the newly described REAL classification categories and investigated for the expression of the cyclin D1, bcl-2, p53 and bcl-6 protein by the immunohistochemical method.
Results : There were higher rates of extranodal lymphoma, diffuse large B cell lymphoma, and angiocentric lymphoma and lower rates of T cell lymphoma and follicular center lymphoma compared with Western countries. Cyclin D1 is expressed in all cases of MCL. But no cases except for MCL showed positive for cyclin D1. The expression of bcl-2 had decreased in high-grade lymphomas.
Conclusion : It suggests that the cyclin D1 expression in mantle cell lymphoma could be reliably distinguished from its expression in other non-Hodgkin’ s lymphomas. In addition, bcl-2 may be useful for the differentiation of the low grade lymphoma from the high grade lymphoma.
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KEYWORD
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Non-Hodgkin’s lymphoma, Cyclin D1, Bcl-2, p53, Bcl-6
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